Research Fellow in Neurogenetics and Gene Therapy(UK Visa Sponsorship)

Automotive Jobs, Health and Care
Uk
December 18, 2025
Full Time Permanent
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Job Description

The Cortese Laboratory

This position is based in the Cortese Laboratory, which specialises in identifying and modelling novel genetic causes of inherited neuropathies and neurodegenerative diseases. The lab has particular expertise in repeat expansion disorders and pathogenic variants located in non-coding regions of the genome.

A central focus of the group is RFC1-related CANVAS, a common and underdiagnosed adult-onset neurological condition. The lab has generated landmark findings demonstrating tissue-specific reduction of RFC1 expression associated with AAGGG repeat expansions, impaired DNA repair function, and increased sensitivity to genotoxic stress. These discoveries underpin an ambitious therapeutic programme aimed at restoring RFC1 function.

The Role

We are seeking a highly motivated Research Fellow to contribute to the development of novel therapies for repeat expansion disorders, with a primary focus on RFC1 CANVAS. The post-holder will work under the supervision of Professor Andrea Cortese, in close collaboration with Professor Joanne Ng (Genetic Therapy Accelerator Centre) and Professor Fiona Ducotterd (ARUK UCL Drug Discovery Institute).

You will join a multidisciplinary team delivering cutting-edge RNA-based and AAV-mediated gene therapy projects, spanning in vitro systems and in vivo models. The role offers the opportunity to contribute directly to a translational research programme with clear clinical relevance.

This position is funded by a prestigious European Research Council (ERC) Award.

Key Responsibilities

Research and Experimental Work

  • Design and conduct experiments supporting gene reprovision and endogenous gene upregulation strategies for RFC1.
  • Apply CRISPR/Cas9-based genome editing and gene perturbation approaches.
  • Generate and characterise iPSC-derived neuronal models.
  • Produce and test AAV vectors for therapeutic delivery.
  • Contribute to small-molecule screening and modifier discovery pipelines.

Collaboration and Communication

  • Work closely with internal and external collaborators across genetics, drug discovery, and gene therapy.
  • Analyse, interpret, and present experimental data.
  • Contribute to manuscripts, reports, and funding-related outputs.
  • Support the wider research environment through shared laboratory activities.

About You

You will be an enthusiastic and skilled postdoctoral researcher with:

  • A PhD (or near completion) in molecular biology, neurogenetics, gene therapy, drug discovery, or a related discipline.
  • Strong practical experience in molecular cloning and CRISPR-based genome editing.
  • Postdoctoral or equivalent research experience in one or more of the following: AAV gene therapy, iPSC-based disease modelling, gene perturbation, or drug screening.
  • Proven competence in human cell culture, including neuronal models.
  • Experience with AAV production and Fluorescence-Activated Cell Sorting (FACS).
  • If the PhD has not yet been formally awarded, appointment will initially be made at Research Assistant level, with automatic backdating upon PhD completion.

What We Offer

UCL provides an inclusive and supportive research environment, alongside a comprehensive benefits package:

  • 41 days of leave per year (annual leave, bank holidays, and closure days)
  • Defined benefit career-average pension scheme (CARE)
  • Additional annual leave purchase option
  • Immigration loan and visa support (where applicable)
  • Cycle-to-work scheme and season ticket loans
  • On-site nursery, gym, and wellbeing services
  • Enhanced family leave and employee assistance programmes

Equality, Diversity and Inclusion

The Institute of Neurology is committed to fostering an inclusive, respectful, and collaborative working culture. Individual strengths are recognised and valued, and career development is actively supported. The Institute holds an Athena SWAN Silver Award in recognition of its progress towards gender equality.

UCL warmly encourages applications from candidates who are underrepresented in academic research, including people from Black, Asian and ethnic minority backgrounds, disabled people, LGBTQI+ and gender-diverse communities, and women in senior research roles.

Application Process

To apply, please submit:

  • A current CV
  • A completed online application form
  • A supporting statement or cover letter addressing the essential and desirable criteria
  • Please do not upload additional documents, as these will not be considered by the selection panel.

Relevant UK Government Context and Guidance

This role aligns with national priorities in biomedical research, advanced therapies, and skills development. Applicants may find the following UK government resources useful:

Visa and Employment Information

This role meets eligibility requirements for sponsorship under the Skilled Worker and Global Talent visa routes. Appointments are subject to UCL Terms and Conditions of Service for Research and Professional Services Staff.

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