Research Fellow(UK Visa Sponsorship)

Job Description

About the Department

The Department of Neurodegenerative Disease is internationally recognised for its research into disorders that cause dementia and related neurological conditions. Our work spans genetic, molecular, cellular, and neuropathological mechanisms that drive neurodegeneration, with a strong emphasis on connecting molecular pathology to real-world clinical outcomes.

Within the Department, Professor Helene Plun-Favreau’s laboratory focuses on understanding how dysfunction of cellular organelles contributes to Parkinson’s disease and other neurodegenerative conditions, with the goal of identifying disease-relevant mechanisms and potential therapeutic targets.

About the Role

We are seeking a highly motivated Research Fellow to join a multidisciplinary research team investigating the molecular mechanisms of a newly identified Parkinson’s disease risk gene.

The successful candidate will work on an innovative project exploring how this candidate gene regulates mitochondria–lysosome contact sites (MLCs) and mitophagy, two processes central to Parkinson’s disease pathogenesis. The project combines advanced cellular models with state-of-the-art experimental approaches to uncover how disruptions in these pathways contribute to neurodegeneration.

You will be embedded in a collaborative environment that brings together expertise in imaging, molecular biology, biochemistry, and bioinformatics, offering strong opportunities for scientific development and publication.

This position is funded by Parkinson’s UK and is available until 28 February 2029 in the first instance.

Key Responsibilities

• Investigate the function of a Parkinson’s disease–associated risk gene in human neuronal models
• Study mitochondria–lysosome interactions and mitophagy using advanced microscopy techniques
• Apply molecular biology and biochemical approaches to dissect disease mechanisms
• Analyse and interpret experimental data using appropriate bioinformatics tools
• Collaborate closely with researchers across disciplines and contribute to publications and presentations

About You

You will have (or be close to completing) a PhD in Neuroscience, Molecular Biology, Biochemistry, or a closely related discipline. You should bring hands-on research experience and a strong interest in neurodegenerative disease mechanisms.

Essential criteria include:

• Practical experience with electron microscopy and advanced imaging techniques
• Strong background in molecular biology and biochemistry
• Working knowledge of mitophagy, mitochondria–lysosome contact sites, or related cellular pathways
• Excellent communication skills and the ability to work effectively within a team
• Experience working with human neuronal models and large biological datasets will be considered an advantage.

Salary and Contract Details

Research Fellow salary: £45,103 per annum (inclusive of London Allowance)

If the PhD has not yet been formally awarded, the initial appointment will be made at Research Assistant level (£39,148–£41,833), with automatic backdated promotion upon PhD completion

This role meets the eligibility requirements for UK Skilled Worker and Global Talent visas, and international applicants are warmly encouraged to apply.

Relevant UK Government guidance:

• Skilled Worker visa
• Global Talent visa
• Right to work in the UK
• UK research immigration routes
• Equality and employment rights

What We Offer

UCL offers an outstanding employment package designed to support both professional success and personal wellbeing, including:

• 41 days of annual leave (including bank holidays and closure days)
• Generous defined-benefit pension scheme (CARE)
• Flexible working arrangements, including part-time and job-share options where feasible
• Cycle-to-work scheme, season ticket loans, and immigration loan support
• On-site nursery, gym facilities, and enhanced family leave policies
• Comprehensive wellbeing and employee assistance services

Equality, Diversity and Inclusion

We are committed to creating a welcoming, inclusive, and supportive research environment where everyone can thrive. The Institute actively promotes equality and diversity through targeted initiatives and holds an Athena SWAN Silver Award in recognition of its work to advance gender equality.

We strongly encourage applications from individuals who are underrepresented in higher education and research, including candidates from Black, Asian and minority ethnic backgrounds, disabled people, LGBTQI+ individuals, and women in senior research roles.

How to Apply

To apply, please submit:

• A current CV
• An online application form

A supporting statement or cover letter clearly demonstrating how you meet the essential and desirable criteria