Research Fellow in Mitochondrial Medicine(UK visa sponsorship available)

Job Description

About Us

The Department of Clinical and Movement Neurosciences is internationally recognized for research into rare and acquired neurodegenerative disorders. Within the department, Professors Spinazzola and Holt lead a pioneering research group in mitochondrial medicine. Their work has included the first discovery of pathological mutations in mitochondrial DNA (mtDNA) and nuclear genes linked to mtDNA instability. Building on this foundation, the group continues to explore disease mechanisms and test potential therapies for currently incurable mitochondrial disorders.

The Role

We are seeking a Research Fellow to join Professors Spinazzola and Holt’s team, focusing on investigating how specific compounds may be used to treat mitochondrial diseases.

Your main project will explore compounds that selectively remove harmful mtDNA molecules (PMID: 34873176; 35478201; 38402076). The work will involve:

Studying the impact of small molecules on neurons and cardiomyocytes, the cell types most affected in mtDNA disorders.

Identifying metabolic states that encourage the selection of functional mtDNA.

Mapping the molecular events that connect mitochondrial dysfunction to disease progression.

As part of a collaborative team, you will use targeted and omic approaches with patient-derived stem cell models and transgenic mouse models. The findings will help advance treatments toward clinical application.

This role is funded until 30 April 2027.

About You

You will hold a PhD or MD in Neuroscience, Developmental Biology, Molecular Biology, or a related discipline. Essential skills include:

Strong expertise in Biochemistry/Molecular Biology

Experience working with stem cell-derived models

The position is open to international candidates and meets UKVI eligibility for a Skilled Worker visa or Global Talent visa.

What We Offer

Appointment as Research Fellow requires a PhD award. Candidates who have submitted their thesis but not yet been awarded will be appointed as Research Assistant (£39,148 – £41,833), with backdated promotion to Research Fellow upon award.

A comprehensive benefits package, including:

41 days’ holiday (27 days annual leave + 8 bank holidays + 6 closure days)

Defined benefit pension scheme

Cycle-to-work and season ticket loan schemes

Immigration loan support

On-site nursery and gym

Enhanced parental leave pay

Staff support services and discounted medical insurance

Full details: UCL Reward & Benefits

Application Process

Applicants must submit:

A full CV

A 1-page research statement explaining their suitability and motivation

Our Commitment to Equality, Diversity, and Inclusion

UCL values diversity as a driver of innovation and creativity. We particularly welcome applications from underrepresented groups, including candidates from Black, Asian and minority ethnic backgrounds, disabled candidates, LGBTQI+ and gender diverse applicants, and women at senior research levels.

We hold an Athena SWAN Silver award in recognition of our commitment to gender equality.