Research Assistant / Research Fellow

Job Description

About the Role

We are recruiting a Research Assistant / Research Fellow to join Dr Paula Alexandre’s group within the Human Developmental Biology Initiative (HDBI

This project aims to investigate human hindbrain development, focusing on progenitor zones in the cerebellum and brainstem. The post-holder will:

Develop human hindbrain tissue culture and apply sparse cell labelling (e.g. DiI, viral vectors, plasmid electroporation) for long-term live imaging.

Study progenitor proliferation and migration behaviours.

Use single-cell barcoding and RNA sequencing to identify cell types and reconstruct cell lineages.

Carry out histological analysis to characterize progenitor zones.

The research will build on recent findings (Haldipur et al, Science 2019) showing expanded progenitor zones and unique human cell types, with the aim of generating new insights into both normal development and the causes of hindbrain malformations.

About You

We are seeking a creative, motivated and well-organized researcher with:

A PhD (for appointment at Grade 7) or Master’s degree / equivalent experience (for Grade 6B) in neurobiology or a related field.

Experience in cell and explant culture, live imaging, and single-cell methods (desirable).

Strong technical and analytical skills, with the ability to work independently and collaboratively.

Please note: Appointment at Grade 7 requires a PhD. If not yet awarded, candidates will initially be appointed at Grade 6B, with promotion to Grade 7 backdated to the date of final PhD submission.

This role provides an exciting opportunity to contribute to cutting-edge research in human brain development within a supportive and collaborative academic environment.