Research Fellow – Lung Cancer Biology (APOBEC3 & Tumorigenesis)UK Sponsorship

Job Description

About the Institution

University College London (UCL) is globally recognised for its research excellence and innovation in biomedical sciences. Within its Division of Medicine, the Respiratory Department provides a highly collaborative and well-equipped environment for translational cancer research.

The Lung Cancer Prevention Laboratory, led by Deborah Caswell, is focused on understanding the earliest biological events that drive lung cancer development. The lab benefits from strong collaborations, including work with Sam Janes, providing access to large-scale clinical datasets and patient samples from major studies such as SUMMIT and ASCENT.

Researchers in this group work with cutting-edge tools, including advanced histology platforms, humanised mouse models, and unique cancer cell line systems that are not widely available elsewhere.

About the Role

This Research Fellow position offers an opportunity to lead an innovative project investigating how APOBEC3 enzymes influence the early stages of lung cancer development, particularly in never-smokers with EGFR mutations.

The role will involve working with a novel humanised mouse model designed to mimic human lung cancer biology. You will explore how APOBEC3 activity contributes to DNA mutations, structural genomic damage, and changes in the tumour immune environment.

Key Responsibilities

Design and deliver a high-quality research programme aligned with project goals
Conduct laboratory experiments using advanced in vivo and cellular models
Investigate mutational processes and immune responses in tumour development
Analyse experimental data and translate findings into impactful publications
Collaborate with internal and external research partners
Review scientific literature to inform ongoing research

This position is funded for three years, with opportunities to apply for additional fellowships and potential extension based on performance.

Candidate Requirements

Essential Criteria

PhD in a relevant biological science (e.g., cancer biology, molecular biology, or related field)
Proven ability to conduct independent and original research
Strong understanding of lung cancer biology and experimental models
Experience working with animal models, particularly mouse models of cancer
Demonstrated scientific writing skills and publication record

Personal Qualities

Highly motivated and organised
Collaborative mindset with strong interpersonal skills
Commitment to scientific excellence and innovation

Visa and International Applicants

This role is eligible for UK visa sponsorship, making it accessible to international candidates.

Helpful official resources include:

UK Visas and Immigration – Skilled Worker visa
Global Talent visa for researchers
Guidance on working in the UK
Proving your right to work
UK research and innovation careers

Benefits and Working Environment

UCL offers a supportive and rewarding working environment, including:

41 days annual leave (including bank holidays and institutional closure days)
Option to purchase additional annual leave
Competitive pension scheme (CARE)
Relocation and immigration support (where applicable)
Cycle-to-work scheme and travel loans
On-site nursery and fitness facilities
Enhanced parental leave policies
Staff wellbeing and support programmes
Access to private medical insurance discounts

Equality, Diversity & Inclusion

UCL is committed to creating an inclusive and diverse research community. Applications are particularly encouraged from individuals who are underrepresented in academia, including ethnic minorities, disabled individuals, and LGBTQI+ candidates.

The department holds an Athena SWAN Silver Award, recognising its ongoing efforts to advance gender equality and inclusive practices.

How to Apply

Applicants should submit:

A current CV
Completed application form
A supporting statement outlining how they meet the role criteria