Research Fellow(UK Visa Sponsorship)

Job Description

About the Institute

The UK Dementia Research Institute (UK DRI) is a world-leading centre tackling neurodegenerative diseases, including Alzheimer’s and other dementias. With over 900 researchers, the institute spans multiple disciplines to accelerate discovery, development, and delivery of interventions aimed at diagnosis, treatment, and prevention.

The Bourdenx Lab, led by Dr Mathieu Bourdenx, focuses on understanding how age-related loss of cellular fitness drives neurodegeneration. By combining molecular cell biology with cutting-edge spatial and single-cell technologies, and computational approaches including AI-driven hypothesis generation, the lab seeks to uncover mechanisms and potential therapeutic targets in dementia.

For context on UK dementia research priorities, see: NIHR Dementia Research

Role Overview

We are seeking a Research Fellow to explore neuronal vulnerability to proteostasis collapse in ageing and neurodegenerative diseases. You will use an integrative approach combining wet-lab spatial biology, single-cell omics, and computational analysis to understand selective neuronal degeneration.

Key responsibilities include:

• Mapping molecular signatures of proteostasis failure using spatial omics pipelines
• Identifying early markers of protein homeostasis collapse
• Working across model systems: iPSC-derived neurons, mouse models, and human post-mortem tissue
• Collaborating with multidisciplinary teams to analyse data and interpret results
• Contributing to grant writing, publications, and scientific presentations
• The post is available immediately and funded by the Medical Research Council until 31 March 2027.
• For guidance on conducting safe and ethical neuroscience research in the UK: UKRI Research Ethics

Candidate Profile

We welcome candidates who have:

• A PhD in Neuroscience, Biology, Physiology, Medicine, or a related discipline (or nearing completion)
• Experience with histology (perfusions, cryostat sectioning), immunohistochemistry, immunofluorescence, in situ hybridisation, and microscopy
• Skills in molecular biology techniques (RNA extraction, AAV vector design)
• Proficiency in computational analysis using Python or R, including good programming practices (version control, reproducibility)
• Solid foundation in cell biology and neuroscience, including anatomy and pathological mechanisms
• Excellent communication, interpersonal, and teamwork skills, and the ability to work independently
• For UK-specific guidance on good laboratory practice and research integrity, see: Gov.uk Research Integrity Guidance

Eligibility

This role meets the requirements for a Skilled Worker Certificate of Sponsorship or a Global Talent visa under UK Visas and Immigration legislation. International applicants are welcome to apply.

Benefits

UCL provides a supportive and flexible environment with benefits including:

• 41 days holiday (27 days annual leave, 8 bank holidays, 6 closure days)
• Option to purchase 5 additional days’ leave
• Defined benefit CARE pension scheme
• Cycle-to-work scheme, season ticket loans, and immigration loans
• On-site gym and nursery
• Enhanced maternity, paternity, and adoption pay
• Employee Assistance Programme and discounted medical insurance

Additional UK resources for professional development and research careers:

• NIHR Research Careers and Development
• Gov.uk Flexible Working Guidance
• UKRI Skills and Training Opportunities
• Gov.uk Workplace Equality and Inclusion
• Health and Safety Executive – Lab Safety

Equality, Diversity, and Inclusion

UCL and the UK DRI are committed to creating a diverse and inclusive environment. We actively encourage applications from groups underrepresented in research, including:

Black, Asian, and ethnic minority candidates

Disabled individuals

• LGBTQI+ and gender diverse people
• Women in senior roles (Grade 9 and 10)
• The Institute holds an Athena SWAN Silver award, reflecting demonstrable commitment to gender equality and career progression for all.

How to Apply

Candidates should submit:

• A current CV detailing academic, research, and technical experience
• A covering statement or supporting statement addressing how they meet the essential criteria