Clinical Research Fellow Rare Disease Genomics, ICGNMD-2(UK Visa Sponsorship)
Job Description
About the Research Environment
This fellowship sits within a nationally recognised centre for neuromuscular and spinal cord disease research, combining clinical insight with advanced genomics. The department brings together clinicians, geneticists, and laboratory scientists who aim to uncover disease mechanisms and translate discoveries into meaningful patient therapies.
The Neurogenetics Research Group, led by Henry Houlden, investigates inherited neurological and neuromuscular conditions — including ataxias, hereditary spastic paraplegia, channelopathies, and peripheral nerve disorders — using cutting-edge genomic technologies and clinical phenotyping.
Role Overview
This Clinical Research Fellow position focuses on identifying the genetic drivers of inherited neuromuscular disease in a large, diverse patient cohort.
You will combine laboratory research, clinical exposure, and patient engagement, creating a strong bridge between genomic discovery and real-world clinical practice.
Your responsibilities will include:
- Leading a genomics research project on rare inherited neuromuscular disease
- Participating in multidisciplinary clinical meetings to interpret genetic findings
- Supporting outpatient clinics, including patient consent for research
- Deep phenotyping of genetically unresolved cases
- Contributing to ongoing natural history and therapeutic studies
- There is a strong opportunity to enrol in a PhD programme, using fellowship research to support a long-term clinical academic pathway.
- The post includes an honorary clinical contract with University College London Hospitals NHS Foundation Trust, subject to DBS clearance.
- Funding is provided by the Medical Research Council for an initial year.
Candidate Profile
We are seeking a clinically trained researcher who is motivated to work at the interface of genomics and neurology.
Essential background:
- GMC registration and licence to practise via the General Medical Council
- Clinical neurology experience
- Strong understanding of inherited disease genetics
- Knowledge of research governance, confidentiality, and data protection
- Familiarity with NHS clinical practice and audit
- Evidence of supervised research activity
Desirable experience includes:
- Application of ACMG genetic variant interpretation criteria
- Exposure to advanced DNA/RNA analysis workflows
- Experience working in NHS research environments
- This role is eligible for UK skilled worker or global talent visa pathways.
Salary & Benefits
Salary range: £51,140 – £78,670 per year (inclusive of London allowance), depending on NHS grade and clinical training stage.
Benefits include:
- 41 days total annual leave
- Pension under a CARE scheme
- Cycle-to-work and travel loan schemes
- Immigration loan assistance
- On-site childcare and gym facilities
- Enhanced family leave
- Staff wellbeing services
- Discounted healthcare options
- Flexible and part-time arrangements will be considered where feasible.
Equality, Diversity & Inclusion
The institute actively supports an inclusive working culture where diverse perspectives strengthen research impact. Applications are encouraged from individuals traditionally underrepresented in academic medicine. Ongoing initiatives promote accessibility, equality, and professional development for all staff.
Relevant UK Government Resources
Applicants — particularly those entering clinical research or relocating internationally — may find these official resources useful:
- Medical registration and professional standards
- Skilled worker visa overview
- Data protection and GDPR responsibilities
- Clinical research governance framework
- NHS employment and working guidance
